Amount funded: $19,954
Co-PI: W. Larry Kenney, Department of Physiology and Kinesiology, College of Health and Human Development
Co-PI: Nina G. Jablonski, Department of Anthropology, College of the Liberal Arts
Co-I: Anna E. Stanhewicz, Center for Healthy Aging, College of Health and Human Development
Co-I: Tyler B. Garner, Intercollege Graduate Program in Physiology, College of Health and Human Development, Huck Institutes
This research proposal aims to examine the effects of skin pigmentation on NO bioavailability and NO-mediated vasodilation in the cutaneous microcirculation following acute and repeated UVR exposure. The proposed experiments utilize innovative in vivo techniques and call on a wide range of expertise achieved through collaborations from faculty in the departments of Anthropology, Kinesiology, and Physiology at Penn State University. Three specific questions will be addressed: (1) What specific mechanisms of NO-mediated vasodilation are affected during and immediately following acute exposure to UVR? (2) Does darker skin pigmentation protect against UVR-induced impairments in NO bioavailability and cutaneous vasodilation? (3) Does impaired NO-mediated dilation persist in the cutaneous microvasculature following repeated UVR exposures and are these impairments attenuated by folate supplementation?