Penn State Penn State: College of the Liberal Arts

Center forHuman Evolution and Diversity

Historically studies in neuroscience have presented their findings regarding how the brain works as universal to all humans, whereas studies in anthropology have focused on the great cross-cultural diversity in behavior and thought. Furthermore, studies of the human brain and mind are typically conducted with samples that are highly unrepresentative of the global population. Therefore, in order to truly understand the functions of the brain and mind across the spectrum of human diversity, it is necessary to integrate theory and methods from anthropology, psychology and neuroscience.

Elizabeth Losin, Associate Professor of Biobehavioral Health

There is an urgent imperative to unbias human microbiome studies across the diversity of all of us to solve the major challenges relating to health disparities and inequities. More precise and personalized approaches must take into account microbial influences on and responders to our lived experiences. Without a sense of urgency and mission, the generalizability of microbiome findings across populations will be limited and likely generate new cascading health disparities.

Seth Bordenstein, Director of the Microbiome Center, Professor of Biology and Entomology

Reconstructing human ecosystems of the past and their evolution provides not only a window into the past but helps us better plan for the future. We can use information from our ancestors to improve our lives tomorrow.

Laura Weyrich, Associate Professor of Anthropology

Quite simply, the only way we will make meaningful progress in solving “wicked problems” of today and tomorrow is to take a holistic approach, drawing upon both depth and breadth of expertise from multiple disciplines and recognizing the importance of diverse perspectives and experiences.

Jennifer Wagner – Assistant Professor of Law, Policy, and Engineering

One of the strongest evolutionary influences on humans has been largely invisible: microbes. Interdisciplinary approaches that incorporate evolution, microbiology, genetics, physiology, and more are necessary to reveal how we interact with microbes and how these trans-kingdom interactions affect both evolution and health.

Emily Davenport – Assistant Professor of Biology

Our history of conquest, colonization, and massive forced migration has created a profound and long-lasting social and cultural legacy, and these actions also left a genomic legacy. Transdisciplinary research is necessary to fully appreciate human diversity, to combat health inequity, and to advance wellbeing for everyone.

Zachary Szpiech – Assistant Professor of Biology

"No factor is more fundamental to human variation than biological sex, and its importance to our health and well-being is becoming increasingly appreciated. A transdisciplinary approach rooted in evolutionary principles is the surest path to understanding the development of sex differences and how these processes contribute to human diversity and influence our lives."

David Puts – CHED Co-Director, Professor of Anthropology

"Our Center is important for two reasons: 1) There are many interesting questions yet to answer about human evolution and physical, behavioral, and genetic variation, and 2) There seems to be a continuing divide between what anthropologists know and how they think about human evolution and diversity and how the general public and academic colleagues in other fields think about these topics."

Mark Shriver – CHED Co-Director, Professor of Biological Anthropology

"Human beings are products of rich and complex interactions between biology and culture that have developed over millions of years. Human evolutionary history informs our understanding of human behavior and culture, and vice versa. Examining only one side of this set of reciprocal interactions risks missing the plot entirely."

Nina Jablonski – Atherton Professor, Evan Pugh University Professor Emerita of Anthropology

“Bringing together multiple disciplines to understand how people learn and reason about complex topics such as human evolution is important for today’s schools, museums, and other educational settings. The Center offers multiple perspectives of how research in this area is conducted, which will enhance young people’s views of how scientific knowledge is developed and of human diversity.”

Heather Toomey Zimmerman – Associate Professor of Education

"If we are to make any headway in fighting diseases, reducing inequalities and the internecine fighting that appears to emerge so endemically when resources are scarce, values differ, and political approaches conflict, we must utilize multiple approaches, methods, be transdisciplinary and take into account the nature of human diversity, at every level, from our genes to our social identifications."

Peter Hatemi – Professor of Political Science

"For problems ranging from infectious disease to racial tensions in American cities, understanding that evolution matters but that genes are not deterministic and differ in their effects depending on social behavior and environment is a powerful way to better understand and solve many human challenges. Interdisciplinary research holds great promise for using our knowledge of evolution effectively to improve the human condition."

Eric Plutzer – Professor of Political Science

"A transdisciplinary study of human evolution and diversity not only helps us understand how and why we became who we are, it is necessary for determining how we function day-to-day. My research examines the effects of biological and self-reported indicators of daily stress on health. How we experience and respond to daily life challenges is intricately tied to the evolution of human diversity."

David Almeida – Professor of Human Development and Family Studies

Are Human Sexually Dimorphic Traits Affected by Variation in Y-Chromosomal Ampliconic Gene Copy Number?

Are Human Sexually Dimorphic Traits Affected by Variation in Y-Chromosomal Ampliconic Gene Copy Number?

Amount funded: $20,000

Project Personnel:

PI: Kateryna Makova, Department of Biology, Eberly College of Science

Co-I: Mark D. Shriver, Department of Anthropology, College of the Liberal Arts

Co-I: David A. Puts, Department of Anthropology, College of the Liberal Arts

Co-I: Michael DeGiorgio, Department of Biology, Eberly College of Science

Co-I: Paul Medvedev, Department of Computer Science and Engineering, College of Engineering, and Dept. of Biochemistry and Molecular Biology, Eberly College of Science

Co-I: Francesca Chiaromonte, Department of Statistics, Eberly College of Science

The goal of the project is to study the variation of ampliconic gene copy number in 100 human males representing the major Y-chromosomal haplogroups; 5 human males per each of 20 Y-haplogroup assayed will be studied. Ampliconic genes are male fertility genes present in multiple copies on the Y chromosome. They are important in reproduction, especially in fertility and spermatogenesis. An undergraduate student is performing Droplet Digital PCR (ddPCR) copy number assays of 9 ampliconic gene families found on the Y chromosome to determine their sizes in each individual.